Hirschsprung´s Disease vs. Normal Rectum
Left picture: In this case an aganglionosis is present which is diagnostic for a Hirschsprung´s disease. Right picture: Normal part of the rectum without signs of a malformation of the intestinal nervous system.
Segments of two deep biopsies of the rectal wall with a lactatedehydrogenase staining. Visible in the lower part of the picture is the intermediate layer between the annular and the longitudinal muscles of the rectum. Left picture: The intermediate layer exhibits no cellular elements, especially no ganglionic cell. Right picture: Dark-stained multinuclear cells are visible in the intermediate layer.